9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

Base Information

Chemical Name:9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine
CAS No.:798574-42-2
Molecular Formula:C₃₂H₃₁N₅O₄
Molecular Weight:549.629
Hs Code.:

Synonyms:9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

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Chemical Property of 9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

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Technology Process of 9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

There total 5 articles about 9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 798574-41-1
2,5-anhydro-3-deoxy-4-O-methanesulfonyl-6-O-trityl-L-talose ethylene acetal

: 798574-42-2
9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

Guidance literature:: adenine; With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

2,5-anhydro-3-deoxy-4-O-methanesulfonyl-6-O-trityl-L-talose ethylene acetal; In N,N-dimethyl-formamide; at 85 ℃; for 72h; Further stages.;
DOI:10.1016/j.tet.2004.08.087

Reference yield:

: 258336-20-8
2,5-anhydro-3-deoxy-L-talose ethylene acetal

: 798574-42-2
9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 24 h / 20 °C

2: Et₃N / 0.5 h / 20 °C

3: NaH / dimethylformamide / 72 h / 80 - 85 °C

With pyridine; sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-200060036

Reference yield:

: 798574-46-6
2,5-anhydro-3-deoxy-6-O-trityl-L-talose ethylene acetal

: 798574-42-2
9-((2R,3R,5R)-5-[1,3]Dioxolan-2-yl-2-trityloxymethyl-tetrahydro-furan-3-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / 0.5 h / 20 °C

2: NaH / dimethylformamide / 72 h / 80 - 85 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-200060036