Piperacillin sodium salt

Base Information

• Chemical Name: Piperacillin sodium salt
• CAS No.: 59703-84-3
• Molecular Formula: C23H26N5NaO7S
• Molecular Weight: 539.545
• Hs Code.: 29411099
• European Community (EC) Number: 261-868-6
• NCI Thesaurus Code: C749
• RXCUI: 203134
• Mol file: 59703-84-3.mol

Synonyms:AB Piperacillin;AB-Piperacillin;Cl 227193;Cl-227193;Cl227193;Curasan, Piperacillin;Monosodium Salt, Piperacillin;Pipcil;Pipera hameln;Pipera-hameln;Piperacillin;Piperacillin curasan;Piperacillin Fresenius;Piperacillin Hexal;Piperacillin Monosodium Salt;Piperacillin ratiopharm;Piperacillin Sodium;Piperacillin-ratiopharm;Pipercillin;Pipracil;Pipril;Salt, Piperacillin Monosodium;Sodium, Piperacillin;T 1220;T-1220;T1220

Chemical Property of Piperacillin sodium salt

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Vapor Pressure: 5.55E-21mmHg at 25°C
• Melting Point: 183-185 °C (dec.)
• Refractive Index: 180 ° (C=0.8, H2O)
• Boiling Point: 707.1oC at 760 mmHg
• Flash Point: 381.4oC
• PSA: 184.56000
• Density: ==
• LogP: -0.97950
• Storage Temp.: Store at 0-5°C
• Solubility.: H2O: 50 mg/mL, clear, colorless to faintly yellow
• Water Solubility.: Soluble in ethanol, water and methanol.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 540.15288867
• Heavy Atom Count: 37
• Complexity: 982

Purity/Quality:

99% ^*data from raw suppliers

Piperacillin sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O.[Na]
• Isomeric SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O.[Na]
• Recent ClinicalTrials: Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count
• Recent EU Clinical Trials: Antibiotic pharmacokinetics in women with twin pregnancy
• Recent NIPH Clinical Trials: None
• Uses: Penicillin antibacterial. An antibiotic related to penicillin A broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria. Piperacillin sodium salt is an antibiotic. It is used in pharmacokinetic studies to optimize antimicrobial therapy and in hypersensitivity reactions. It is involved in the study of multidrug-resistant organisms. It acts as an antibiotic related to penicillin.

Technology Process of Piperacillin sodium salt

There total 2 articles about Piperacillin sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperacillin (61477-96-1,64131-97-1) → sodium piperacillin (59703-84-3)

Guidance literature:

With sodium hydrogencarbonate; In water;

Reference yield:

tazobactam acid (89786-04-9,115546-66-2,124995-08-0) + piperacillin (61477-96-1,64131-97-1) → sodium piperacillin (59703-84-3) + tazobactam sodium (89785-84-2,115546-70-8)

Guidance literature:

With sodium 2-ethylhexanoic acid; In methanol; water; isopropyl alcohol; at 0 - 35 ℃; for 2.5 - 3.25h; Product distribution / selectivity;

Reference yield:

sodium piperacillin (59703-84-3) → piperacillin (61477-96-1,64131-97-1)

Guidance literature:

With IR-120-[H+] cationic-exchange resin; In water; for 0.5h; pH=3;

DOI:10.1002/jps.21999

upstream raw materials:

piperacillin

tazobactam acid

Downstream raw materials:

piperacillin

Refernces

• 1、 -. "A process for preparing an injectable sterile pharmaceutical formulation containing at least piperacillin sodium and tazobactam sodium as active principles". Page/Page column 2-3. . Retrieved 2008/06/13.