Rosuvastatin ethyl ester

Base Information Edit

Chemical Name:Rosuvastatin ethyl ester
CAS No.:851443-04-4
Molecular Formula:C24H32FN3O6S
Molecular Weight:509.599
Hs Code.:2942000000
Mol file:851443-04-4.mol

Synonyms:Ethyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate;

Suppliers and Price of Rosuvastatin ethyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RosuvastatinEthylEster
1g
$ 125.00

Matrix Scientific
(3R,5S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate 95+%
1g
$ 2016.00

Matrix Scientific
(3R,5S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate 95+%
250mg
$ 908.00

Crysdot
Rosuvastatine 95+%
1g
$ 362.00

Chemenu
ethyl(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate 95%
20mg
$ 122.00

American Custom Chemicals Corporation
ROSUVASTATIN ETHYL ESTER 95.00%
1G
$ 1904.70

AK Scientific
Ethyl(+)-(3R,5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(e)-heptenoate
250mg
$ 1275.00

Total 50 raw suppliers

Chemical Property of Rosuvastatin ethyl ester Edit

Chemical Property:

Vapor Pressure:1.62E-20mmHg at 25°C
Refractive Index:1.571
Boiling Point:699.1 °C at 760 mmHg
PKA:13.39±0.20(Predicted)
Flash Point:376.6 °C
PSA：138.30000
Density:1.294 g/cm³
LogP:3.96100
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

RosuvastatinEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol.

Technology Process of Rosuvastatin ethyl ester

There total 7 articles about Rosuvastatin ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 901765-36-4
(S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxohept-6-enoate

: 851443-04-4
ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate

Guidance literature:: (S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxohept-6-enoate; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 - -75 ℃; for 0.833333h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; for 2h;

With acetic acid; In tetrahydrofuran; methanol;

Reference yield: 96.4%

: 851443-04-4
ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate

Guidance literature:: With sulfuric acid; In dichloromethane; at 38 ℃; for 0.0138889h;

Reference yield: 85.0%

: C₂₄H₃₀FN₃O₆S

: 851443-04-4
ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate

Guidance literature:: C₂₄H₃₀FN₃O₆S; With methanol; diethyl methoxy borane; In tetrahydrofuran; at -78 ℃; for 0.5h;

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at -78 ℃; for 3h;

With sodium hydrogencarbonate; acetic acid; more than 3 stages;