1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

Base Information

Chemical Name:1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane
CAS No.:911482-97-8
Molecular Formula:C₂₄H₂₉O₅P
Molecular Weight:428.465
Hs Code.:

Synonyms:1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

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Chemical Property of 1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

Chemical Property:

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Technology Process of 1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

There total 3 articles about 1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 911482-96-7
5,7-dioxa-6,6-diphenyl-1-formylspiro[2.5]octane

: 1660-94-2
Tetraethyl methylenediphosphonate

: 911482-97-8
1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

Guidance literature:: Tetraethyl methylenediphosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

5,7-dioxa-6,6-diphenyl-1-formylspiro[2.5]octane; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1081/NCN-200067409

Reference yield:

: 911482-95-6
5,7-dioxa-6,6-diphenyl-1-hydroxymethylspiro[2.5]octane

: 911482-97-8
1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / oxalyl chloride; dimethylsulfoxide; triethylamine / CH₂Cl₂ / -50 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 82 percent / tetrahydrofuran; hexane / 1 h / -78 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1.1: Swern oxidation / 2.2: Horner-Wittig reaction;
DOI:10.1081/NCN-200067409

Reference yield:

: (1SR,7RS)-3,5-dioxa-4,4-diphenylbicyclo[5.1.0]octane-1-methanol

: 911482-97-8
1-(E)-(diethoxyphosphinyl)ethenyl-5,7-dioxa-6,6-diphenylspiro[2.5]octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 43 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran / 12 h / 20 °C

2.1: 87 percent / oxalyl chloride; dimethylsulfoxide; triethylamine / CH₂Cl₂ / -50 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 82 percent / tetrahydrofuran; hexane / 1 h / -78 °C

With n-butyllithium; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 2.1: Swern oxidation / 3.2: Horner-Wittig reaction;
DOI:10.1081/NCN-200067409