N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide

Base Information

• Chemical Name: N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide
• CAS No.: 142797-01-1
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 142797-01-1.mol

Synonyms:N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide

Chemical Property of N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide

There total 6 articles about N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

((1R,2S,6S,7S)-4,4-Dimethyl-3,5,8-trioxa-9-aza-tricyclo[5.2.2.02,6]undec-10-en-9-yl)-phenyl-methanone → N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide (142797-01-1)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 25 ℃;

DOI:10.1021/ol000057q

Reference yield:

Carbonic acid (3aR,4S,7R,7aS)-7-benzoylamino-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl ester methyl ester → N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide (142797-01-1)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1021/ja00145a038

Reference yield:

benzoic acid (65-85-0,8013-63-6) → N-((3aS,4R,7S,7aR)-7-Hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl)-benzamide (142797-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylphosphine

2: K₂CO₃ / methanol

With potassium carbonate; trimethylphosphane; In methanol;

DOI:10.1021/ja00145a038

upstream raw materials:

benzoic acid

(1S,4R,5S,6R)-4-azido-5,6-(isopropylidenedioxy)cyclohex-2-enyl methyl carbonate

Carbonic acid (3aS,4R,7S,7aR)-7-methoxycarbonyloxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl ester methyl ester

cis-2,2-dimethyl-3a,4,7,7a-tetrahydrobenzo[1,3]dioxole-4,7-diol