(2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

Base Information

Chemical Name:(2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide
CAS No.:213134-94-2
Molecular Formula:C₂₀H₂₆N₄O₅
Molecular Weight:402.45
Hs Code.:

Synonyms:(2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

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Chemical Property of (2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

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Technology Process of (2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

There total 7 articles about (2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 213134-93-1
(2S,4S)-4-[[[1-benzyloxycarbonylpyrrolidine-2-carbonyl]amino]piperidin-1-yl]acetic acid ethyl ester

: 213134-94-2
(2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

Guidance literature:: With ammonia; In methanol; at -40 - 20 ℃; for 15h;
DOI:10.1055/s-1998-1786

Reference yield:

: 161561-98-4
(3S)-methanesulfonic acid 4-cyano-3-(N,N-dibenzylamino)butyl ester

: 213134-94-2
(2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 82 percent / NH₃ / methanol / 96 h / 20 °C

2.1: 70 percent / HCl / methanol; H₂O / 12 h / 60 °C

3.1: KH / tetrahydrofuran / 0.5 h / 0 °C

3.2: 96 percent / tetrahydrofuran / 23 h / 4 - 20 °C

4.1: 70 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 °C

5.1: 61 percent / HOBt; DCC / tetrahydrofuran / 22 h / 0 - 20 °C

6.1: 85 percent / NH₃ / methanol / 10 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; potassium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo000555c

Reference yield:

: 213134-91-9
(4S)-4-(N,N-dibenzylamino-2-oxopiperidin-1-yl)acetic acid ethyl ester

: 213134-94-2
(2S,4S)-4-[[[1-benzyloxycarbonyl-2-pyrrolidinyl]carbonyl]amino](2-oxopiperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 °C

2: 61 percent / HOBt; DCC / tetrahydrofuran / 22 h / 0 - 20 °C

3: 85 percent / NH₃ / methanol / 10 h / 20 °C

With ammonia; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/jo000555c