C₁₇H₂₁⁽²⁾H₅Si

Base Information

• Chemical Name: C₁₇H₂₁⁽²⁾H₅Si
• CAS No.: 1401307-49-0
• Molecular Formula: C₁₇H₂₆Si
• Molecular Weight: 263.439
• Mol file: 1401307-49-0.mol

Synonyms:C₁₇H₂₁⁽²⁾H₅Si

Chemical Property of C₁₇H₂₁⁽²⁾H₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₁₇H₂₁⁽²⁾H₅Si

There total 1 articles about C₁₇H₂₁⁽²⁾H₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

bromobenzene-d5 (4165-57-5) + tris-iso-propylsilyl acetylene (89343-06-6) → C17H21(2)H5Si (1401307-49-0)

Guidance literature:

With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; at 100 ℃; for 1.5h; Inert atmosphere;

Reference yield: 61.0%

C17H21(2)H5Si (1401307-49-0) → ethynylbenzene-D5 (25837-46-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; Inert atmosphere;

Reference yield:

C17H21(2)H5Si (1401307-49-0) → 5′-O-(t-butyldimethylsilyl)-3′-deoxy-3′-(5-deutero-4-(phenyl-D5)-1H-1,2,3-triazol-1-yl)thymidine (1401307-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / diethyl ether; tetrahydrofuran

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate; water-d2 / dichloromethane / 8 h / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; water-d2; sodium L-ascorbate; In tetrahydrofuran; diethyl ether; dichloromethane; 2: |Huisgen Cycloaddition;

DOI:10.1021/jo301146j DOI:10.1021/jo301146j

upstream raw materials:

bromobenzene-d5

tris-iso-propylsilyl acetylene

Downstream raw materials:

ethynylbenzene-D5

5′-O-(t-butyldimethylsilyl)-3′-deoxy-3′-(5-deutero-4-(phenyl-D₅)-1H-1,2,3-triazol-1-yl)thymidine

5-deutero-1,4-diphenyl-D₁₀-1H-1,2,3-triazole