(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

Base Information

Chemical Name:(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol
CAS No.:106074-86-6
Molecular Formula:C₂₆H₄₅NO₆Si
Molecular Weight:495.732
Hs Code.:

Synonyms:(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

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Chemical Property of (2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

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Technology Process of (2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

There total 10 articles about (2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 106074-85-5
(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutyl acetate

: 106074-86-6
(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

Guidance literature:: With potassium carbonate; In methanol; 1) 0 deg C, 1 h, 2) 5 deg C, 1 h, 3) RT, 1.5 h;
DOI:10.1016/S0040-4020(01)87959-X

Reference yield:

: 97322-35-5
(2R,3S)-2-(tert-butoxycarbonyl)amino-3,4-epoxybutyl acetate

: 106074-86-6
(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

Guidance literature:: Multi-step reaction with 3 steps

2: 98 percent / dl-10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 0 °C

3: 82 percent / K₂CO₃ / methanol / 1) 0 deg C, 1 h, 2) 5 deg C, 1 h, 3) RT, 1.5 h

With camphor-10-sulfonic acid; potassium carbonate; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)87959-X

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 106074-86-6
(2R,3R)-2-(tert-butoxycarbonyl)amino-3-(tetrahydropyranyl)oxy-4-<4-(tert-butyldimethylsilyl)oxy>phenylbutanol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / dl-10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 0 °C

2: 82 percent / K₂CO₃ / methanol / 1) 0 deg C, 1 h, 2) 5 deg C, 1 h, 3) RT, 1.5 h

With camphor-10-sulfonic acid; potassium carbonate; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)87959-X