4-Bromo-2,6-dimethylpyridine

Base Information

• Chemical Name: 4-Bromo-2,6-dimethylpyridine
• CAS No.: 5093-70-9
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.051
• Hs Code.: 29349990
• Mol file: 5093-70-9.mol

Synonyms:2,6-Lutidine,4-bromo- (6CI,7CI,8CI);4-Bromo-2,6-lutidine;

Chemical Property of 4-Bromo-2,6-dimethylpyridine

Chemical Property:

• Vapor Pressure: 0.327mmHg at 25°C
• Melting Point: 28-32°C
• Refractive Index: 1.547
• Boiling Point: 207.3 °C at 760 mmHg
• PKA: 5.41±0.10(Predicted)
• Flash Point: 79.2 °C
• PSA: 12.89000
• Density: 1.416 g/cm³
• LogP: 2.46090
• Storage Temp.: 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

4-Bromo-2,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-37/38
• Safety Statements: 26-39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2,6-dimethylpyridine is a reagent used in the synthesis of novel isoquinoline derivatives of potential interest for pharmaceutical, biomedical, and energy-related research.

Technology Process of 4-Bromo-2,6-dimethylpyridine

There total 5 articles about 4-Bromo-2,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,6-dimethylpyridin-4-ol (13603-44-6) → 4-bromo-2,6-dimethylpyridine (5093-70-9)

Guidance literature:

With phosphorus pentabromide; phosphorus(V) oxybromide; In chloroform; at 80 - 110 ℃; for 5h;

Reference yield:

4-amino-2,6-lutidine (3512-80-9) → 4-bromo-2,6-dimethylpyridine (5093-70-9)

Guidance literature:

With copper(I) bromide; Diazotization;

Reference yield:

2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (325142-95-8) → 4-bromo-2,6-dimethylpyridine (5093-70-9)

Guidance literature:

With copper(ll) bromide; In methanol; at 80 ℃;

DOI:10.1021/ja076498n

upstream raw materials:

4-amino-2,6-lutidine

2,6-dimethylpyridin-4-ol

Dehydracetic acid

2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Downstream raw materials:

2,6-dimethyl-4-phenylpyridine

(Z)-2-(2,6-Dimethyl-pyridin-4-yl)-3-phenyl-acrylonitrile

(2,6-dimethylpyridin-4-yl)(phenyl)methanone

Benzenesulfonyl-(2,6-dimethyl-1H-pyridin-4-ylidene)-acetonitrile

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS". Page/Page column 227-228. . Retrieved 2009/01/23.
• 2、 -. "NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS". Page/Page column 59; 60-61. . Retrieved 2008/06/13.