(R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

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Chemical Name:(R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate
CAS No.:1300197-98-1
Molecular Formula:C₂HF₃O₂*C₂₆H₂₄Cl₂N₄O₃
Molecular Weight:625.432
Hs Code.:

Synonyms:(R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

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Chemical Property of (R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

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Technology Process of (R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

There total 4 articles about (R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: (S)-2-amino-3-(3,4-dichloro-phenyl)-N-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-propionamide dihydrochloride

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 76-05-1
trifluoroacetic acid

: 1300197-98-1
(R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Guidance literature:: (S)-2-amino-3-(3,4-dichloro-phenyl)-N-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-propionamide dihydrochloride; D-phenyllactic acid; With benzotriazol-1-ol; In dichloromethane; at 0 ℃; for 0.25h;

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 114873-13-1,80741-39-5
N^α-[(tert-butoxy)carbonyl]-3,4-dichloro-L-phenylalanine

: 1300197-98-1
(R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.25 h

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C

3.2: 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 267876-25-5
5-aminomethylpyrrolo[2,3-b]pyridine

: 1300197-98-1
(R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.25 h

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C

3.2: 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane;