C₃₃H₄₆FN₅O₃

Base Information

• Chemical Name: C₃₃H₄₆FN₅O₃
• CAS No.: 1014703-40-2
• Molecular Formula: C₃₃H₄₆FN₅O₃
• Molecular Weight: 579.758
• Mol file: 1014703-40-2.mol

Synonyms:C₃₃H₄₆FN₅O₃

Chemical Property of C₃₃H₄₆FN₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₆FN₅O₃

There total 12 articles about C₃₃H₄₆FN₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4,6-dimethyl-pyrimidin-5-yl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone (135865-78-0) + C19H26FNO3 (1014703-34-4) → C33H46FN5O3 (1014703-40-2)

Guidance literature:

(4,6-dimethyl-pyrimidin-5-yl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone; C₁₉H₂₆FNO₃; With titanium(IV) isopropylate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 4h;

Reference yield:

4-cyanomethyl-4-(3-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (878130-37-1) → C33H46FN5O3 (1014703-40-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / dichloromethane / 4 h / -78 - -60 °C

2.1: sodium hypochlorite; sodium carbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 20 °C

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

3.2: 20 °C

4.1: tetrahydrofuran / 6 h / -78 - 20 °C

5.1: titanium(IV) isopropylate / tetrahydrofuran; dichloromethane / 0.17 h / 20 °C

5.2: 4 h / 20 °C

With titanium(IV) isopropylate; sodium hypochlorite; diisobutylaluminium hydride; sodium carbonate; 1,1'-carbonyldiimidazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water;

Reference yield:

4-(3-fluoro-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (878130-44-0) → C33H46FN5O3 (1014703-40-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hypochlorite; sodium carbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 20 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

2.2: 20 °C

3.1: tetrahydrofuran / 6 h / -78 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran; dichloromethane / 0.17 h / 20 °C

4.2: 4 h / 20 °C

With titanium(IV) isopropylate; sodium hypochlorite; sodium carbonate; 1,1'-carbonyldiimidazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

(4,6-dimethyl-pyrimidin-5-yl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

C₁₉H₂₆FNO₃

4-(3-fluoro-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

4-cyanomethyl-4-(3-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

C₂₈H₃₈FN₅O

Refernces