(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

Base Information

Chemical Name:(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol
CAS No.:868744-81-4
Molecular Formula:C₂₀H₃₀O
Molecular Weight:286.458
Hs Code.:

Synonyms:(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

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Chemical Property of (E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

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Technology Process of (E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

There total 3 articles about (E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 141694-63-5
(E)-1-iodo-3-phenyl-1-propene

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 868744-81-4
(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

Guidance literature:: (E)-1-iodo-3-phenyl-1-propene; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃; for 1h;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; With trimethylaluminum; In diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1139/V06-095

Reference yield:

: 141694-63-5
(E)-1-iodo-3-phenyl-1-propene

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 868744-81-4
(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

: (E)-(S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

Guidance literature:: (E)-1-iodo-3-phenyl-1-propene; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - 20 ℃; for 2.5h;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; In diethyl ether; pentane; at -78 ℃; for 3h;
DOI:10.1021/ol052034n

Reference yield:

: 10147-11-2
propargyl benzene

: 868744-81-4
(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-4-phenyl-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiEt₃BH; Cp₂ZrCl₂ / tetrahydrofuran / 20 °C

1.2: I₂ / tetrahydrofuran / 20 °C

2.1: t-BuLi / diethyl ether; pentane / 2.5 h / -78 - 20 °C

2.2: AlMe₃ / diethyl ether; pentane; hexane / 3 h / -78 °C

With zirconocene dichloride; tert.-butyl lithium; lithium triethylborohydride; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1021/ol052034n