diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

Base Information

Chemical Name:diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate
CAS No.:1369960-65-5
Molecular Formula:C₂₀H₂₉N₂O₇P
Molecular Weight:440.433
Hs Code.:

Synonyms:diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

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Chemical Property of diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

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Technology Process of diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

There total 4 articles about diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (+/-)-(1R,2R)-diethyl 2-[2-(benzyloxy)ethoxy]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-1-iodoethylphosphonate

: 1369960-65-5
diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 70 ℃; for 5h; Inert atmosphere;
DOI:10.1039/c2ob25131k

Reference yield:

: 13868-21-8,39171-20-5
(E)-Diethyl 2-ethoxyethenylphosphonate

: 1369960-65-5
diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / Inert atmosphere; Reflux

2: iodine / dichloromethane / -30 - 20 °C / Inert atmosphere

3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 5 h / 70 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1039/c2ob25131k

Reference yield:

: 7598-61-0
diethyl phosphonoacetaldehyde diethyl acetal

: 1369960-65-5
diethyl 2-(2-(benzyloxy)ethoxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 6 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / toluene / Inert atmosphere; Reflux

3: iodine / dichloromethane / -30 - 20 °C / Inert atmosphere

4: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 5 h / 70 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1039/c2ob25131k