2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone

Base Information

• Chemical Name: 2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone
• CAS No.: 102104-07-4
• Molecular Formula: C₂₁H₂₅NO₅
• Molecular Weight: 371.433
• Mol file: 102104-07-4.mol

Synonyms:2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone

Chemical Property of 2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone

There total 2 articles about 2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4,6-dihydroxy-2-methoxyacetophenone (3602-54-8) + 2-hydroxyphenyl-bis-1,1-piperidinomethane (20939-20-2) → 2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone (102104-07-4)

Guidance literature:

In ethanol; for 4h; Heating;

DOI:10.1016/S0040-4039(00)94957-8

Reference yield:

1-(2,4,6-trimethoxyphenyl)ethanone (832-58-6) → 2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone (102104-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent Chromat_. / AlCl₃ / chlorobenzene

2: 60 percent / ethanol / 4 h / Heating

With aluminium trichloride; In ethanol; chlorobenzene;

DOI:10.1016/S0040-4039(00)94957-8

Reference yield: 60.0%

2',4'-dihydroxy-3'-((2-hydroxyphenyl)-(1-piperidino)-methyl)-6'-methoxyacetophenone (102104-07-4) → 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxyacetophenone (102056-82-6)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)94957-8

upstream raw materials:

4,6-dihydroxy-2-methoxyacetophenone

2-hydroxyphenyl-bis-1,1-piperidinomethane

1-(2,4,6-trimethoxyphenyl)ethanone

Downstream raw materials:

2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxyacetophenone

uravetin

(2E)-1-[2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenylprop-2-en-1-one

5-C-(o-Benzyloxybenzyl)-4,6-dihydroxy-2-methoxyacetophenone