(2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

Base Information

Chemical Name:(2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester
CAS No.:159846-34-1
Molecular Formula:C₂₆H₃₈N₂O₅Si
Molecular Weight:486.684
Hs Code.:

Synonyms:(2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

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Chemical Property of (2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

Chemical Property:

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Technology Process of (2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

There total 10 articles about (2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 159846-31-8
(2R,3R)-2-Benzylamino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

: 159846-34-1
(2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; Heating;
DOI:10.1016/S0040-4039(00)77016-X

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 159846-34-1
(2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) ImH / 1.) CH₂Cl₂; 2.) DMF

2: 90 percent / HCO₂NH₄ / Pd-C / methanol / Heating

3: P₂O₅ / dimethylsulfoxide / 24 h / Ambient temperature

4: m-CPBA / CH₂Cl₂ / -40 °C

5: Heating

6: 83 percent / HCO₂NH₄ / Pd-C / methanol / Heating

With 1H-imidazole; ammonium formate; phosphorus pentoxide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)77016-X

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 159846-34-1
(2R,3R)-2-Amino-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) ImH / 1.) CH₂Cl₂; 2.) DMF

2: 90 percent / HCO₂NH₄ / Pd-C / methanol / Heating

3: P₂O₅ / dimethylsulfoxide / 24 h / Ambient temperature

4: m-CPBA / CH₂Cl₂ / -40 °C

5: Heating

6: 83 percent / HCO₂NH₄ / Pd-C / methanol / Heating

With 1H-imidazole; ammonium formate; phosphorus pentoxide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)77016-X