n-Fmoc-a-methyl-DL-phenylalanine

Base Information

Chemical Name:n-Fmoc-a-methyl-DL-phenylalanine
CAS No.:212394-94-0
Molecular Formula:C₂₅H₂₃NO₄
Molecular Weight:401.462
Hs Code.:
European Community (EC) Number:970-337-4

Synonyms:n-fmoc-a-methyl-dl-phenylalanine;212394-94-0;MFCD02682285;2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid;2-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)-2-METHYL-3-PHENYLPROPANOIC ACID;Fmoc-|A-methyl-L-phenylalanine;SCHEMBL18237209;2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-3-phenylpropanoic acid;SY066560;CS-0449721;EN300-657845

Suppliers and Price of n-Fmoc-a-methyl-DL-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Activate Scientific
N-Fmoc-a-methyl-DL-phenylalanine 95%
5 g
$ 897.00

Activate Scientific
N-Fmoc-a-methyl-DL-phenylalanine 95%
1 g
$ 324.00

Acrotein
N-Fmoc-a-methyl-DL-phenylalanine 97%
0.5g
$ 146.67

Total 1 raw suppliers

Chemical Property of n-Fmoc-a-methyl-DL-phenylalanine

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:401.16270821
Heavy Atom Count:30
Complexity:594

Purity/Quality:

95%-98% ^*data from raw suppliers

N-Fmoc-a-methyl-DL-phenylalanine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC1=CC=CC=C1)(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of n-Fmoc-a-methyl-DL-phenylalanine

There total 1 articles about n-Fmoc-a-methyl-DL-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1132-26-9
2-methyl-3-phenylalanine

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 212394-94-0,152436-04-9
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-3-phenyl-propionic acid

Guidance literature:: With phosphate buffer; In N,N-dimethyl-formamide; at 0 ℃; for 24h; pH=9 - 10;
DOI:10.1021/ja0348391

Reference yield: 70.0%

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 770-39-8
4-methoxyphenylacetone

: 212394-94-0,152436-04-9
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-3-phenyl-propionic acid

: 91-00-9
Benzhydrylamine

: (1-{Benzhydryl-[1-benzylcarbamoyl-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-carbamoyl}-1-methyl-2-phenyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: In methanol; for 24h; Ambient temperature;
DOI:10.1016/S0960-894X(98)00279-0

Reference yield:

: 212394-94-0,152436-04-9
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-3-phenyl-propionic acid

: (R or S)CαMePhe-Asp(OtBu)-Val-Val-Gly-NH2

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt, DCC / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 24 h

2: 20percent piperidine / dimethylformamide / 0.5 h

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00076a001