4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

Base Information

Chemical Name:4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone
CAS No.:254108-64-0
Molecular Formula:C₂₄H₂₃BrFN₅O₄S
Molecular Weight:576.446
Hs Code.:

Synonyms:4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

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Chemical Property of 4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

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Technology Process of 4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

There total 6 articles about 4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 254108-49-1
2-fluoro-4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

: 676319-77-0
methanesulfonic acid 4-bromo-3-(2-oxo-piperazin-1-ylmethyl)-phenyl ester

: 254108-64-0
4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2003.11.051

Reference yield:

: 267659-64-3
1-[2-Bromo-5-((methanesulfonyl)oxy)benzyl]-2-piperazinone hydrochloride

: 254108-64-0
4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

Guidance literature:: With sodium tris(acetoxy)borohydride; silica gel; In 1,2-dichloro-ethane;

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 254108-64-0
4-[1-(4-Cyano-3-fluorobenzyl)-5-imidazolylmethyl]-1-[2-bromo-5-((methanesulfonyl)-oxy)benzyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: NBS; AIBN / CCl₄ / Heating

3: 92 percent / NaH / dimethylformamide / 0 °C

4: 98 percent / HCl / ethyl acetate / 0 °C

5: 69 percent / NaBH(AcO)3 / 1,2-dichloro-ethane

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; In tetrachloromethane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.11.051