2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol

Base Information

• Chemical Name: 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol
• CAS No.: 121789-62-6
• Molecular Formula: C₁₀H₇Cl₂NO
• Molecular Weight: 228.078
• Mol file: 121789-62-6.mol

Synonyms:2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol

Chemical Property of 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol

There total 8 articles about 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2,4-dichloro-6-aminophenol (527-62-8) + pyrrole (109-97-7,30604-81-0) → 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol (121789-62-6)

Guidance literature:

2,4-dichloro-6-aminophenol; With tert.-butylnitrite; In dimethyl sulfoxide; at 20 ℃; for 0.5h; Inert atmosphere;

pyrrole; With chlorpromazine hydrochloride; In dimethyl sulfoxide; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201900353

Reference yield: 13.0%

2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole (69640-33-1) → 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol (121789-62-6)

Guidance literature:

With boron tribromide; In dichloromethane; at -20 ℃; for 12h;

Reference yield:

3,5-dichloro-2-methoxybenzoyl chloride (5213-08-1) → 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol (121789-62-6)

Guidance literature:

Multi-step reaction with 5 steps

2: glacial acetic acid, conc. HCl / H₂O / 72 h / Ambient temperature

3: glacial acetic acid, conc. HCl / H₂O / 72 h / Ambient temperature

4: 90 percent / CH₃CO₂NH₄ / acetic acid / 0.17 h / Ambient temperature

5: 13 percent / 1M BBr₃ / CH₂Cl₂ / 12 h / -20 °C

With hydrogenchloride; ammonium acetate; boron tribromide; acetic acid; In dichloromethane; water; acetic acid;

upstream raw materials:

2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole

3,5-dichloro-2-methoxybenzoyl chloride

3,5-dichloro-2-methoxybenzoic acid

methyl 3,5-dichloro-2-methoxybenzoate

Downstream raw materials:

2,4-dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)phenol

Refernces

• 1、 Laatsch, Hartmut,Pudleiner, Heinz. "Marine Bacteria, I. - Synthesis of Pentabromopseudiline, a Cytotoxic Phenylpyrrole from Alteromonas luteo-violaceus". . p. 863 - 882. Retrieved 2007/10/02.