toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

Base Information

Chemical Name:toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester
CAS No.:261712-19-0
Molecular Formula:C₂₇H₃₈N₂O₆S₂
Molecular Weight:550.741
Hs Code.:

Synonyms:toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

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Technology Process of toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

There total 8 articles about toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1950-69-2
toluene-p-sulfonyl bromide

: 261712-35-0
(2-tert-butoxycarbonylamino-4-tert-butyl-5-mercapto-phenyl)-carbamic acid tert-butyl ester

: 261712-19-0
toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

Guidance literature:: With pyridine;
DOI:10.1021/ol0056170

Reference yield:

: 5369-19-7
3-tert-butylaniline

: 261712-19-0
toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

Guidance literature:: Multi-step reaction with 7 steps

1: KNO₃ / 0 - 20 °C

2: aq. K₂CO₃ / methanol / 16 h / 20 °C

3: 90 percent / NaBr; Br₂ / 0 - 20 °C

4: 95 percent / H₂ / Raney nickel / tetrahydrofuran / 16 h / 2585.81 Torr

5: 98 percent / ethyl acetate; hexane / 16 h / Heating

6: aq. NaSH; NaBH₄ / methanol / 16 h / 20 °C

7: pyridine

With pyridine; sodium tetrahydroborate; sodium hydrogensulfide; hydrogen; bromine; potassium carbonate; potassium nitrate; sodium bromide; nickel; In tetrahydrofuran; methanol; hexane; ethyl acetate; 1: Nitration / 2: Hydrolysis / 3: thiocyanation / 4: Reduction / 5: Acylation / 6: Reduction / 7: Tosylation;
DOI:10.1021/ol0056170

Reference yield:

: 142564-53-2
5-(tert-butyl)-2-nitroaniline

: 261712-19-0
toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaBr; Br₂ / 0 - 20 °C

2: 95 percent / H₂ / Raney nickel / tetrahydrofuran / 16 h / 2585.81 Torr

3: 98 percent / ethyl acetate; hexane / 16 h / Heating

4: aq. NaSH; NaBH₄ / methanol / 16 h / 20 °C

5: pyridine

With pyridine; sodium tetrahydroborate; sodium hydrogensulfide; hydrogen; bromine; sodium bromide; nickel; In tetrahydrofuran; methanol; hexane; ethyl acetate; 1: thiocyanation / 2: Reduction / 3: Acylation / 4: Reduction / 5: Tosylation;
DOI:10.1021/ol0056170