N²-methyl-5-phenylpyridine-2,3-diamine

Base Information

• Chemical Name: N²-methyl-5-phenylpyridine-2,3-diamine
• CAS No.: 107351-86-0
• Molecular Formula: C₁₂H₁₃N₃
• Molecular Weight: 199.255
• Mol file: 107351-86-0.mol

Synonyms:N²-methyl-5-phenylpyridine-2,3-diamine

Chemical Property of N²-methyl-5-phenylpyridine-2,3-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-methyl-5-phenylpyridine-2,3-diamine

There total 10 articles about N²-methyl-5-phenylpyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

N-methyl-3-nitro-5-phenylpyridin-2-amine (152684-20-3) → N2-methyl-5-phenylpyridine-2,3-diamine (107351-86-0)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; for 0.5h; under 1551.49 Torr;

DOI:10.1016/j.tetlet.2015.09.076

Reference yield:

2-methylamino-3-bromo-5-phenylpyridine (107351-85-9) → N2-methyl-5-phenylpyridine-2,3-diamine (107351-86-0)

Guidance literature:

With ammonium hydroxide; copper(II) sulfate; In water; for 72h; Heating;

Reference yield:

3-phenylpyridine (1008-88-4) → N2-methyl-5-phenylpyridine-2,3-diamine (107351-86-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 58 percent / NaNH₂ / toluene

2: 34 percent / 48percent aq. HBr, Br₂, 12 M HCl, aq. NaNO₂ / 1 h / -5 °C

3: 89 percent / CuSO₄ / H₂O / 48 h / Heating

4: 89 percent / Br₂ / acetic acid

5: 58percent NH₄OH, CuSO₄ / H₂O / 72 h / Heating

With hydrogenchloride; ammonium hydroxide; hydrogen bromide; bromine; sodium amide; copper(II) sulfate; sodium nitrite; In water; acetic acid; toluene;

upstream raw materials:

2-methylamino-3-bromo-5-phenylpyridine

3-phenylpyridine

5-phenyl-pyridin-2-ylamine

2-chloro-5-phenylpyridine

Downstream raw materials:

3-methyl-6-phenyl-2-N-(p-toluenesulfonyl)aminoimidazo[4,5-b]pyridine