(S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate

Base Information

• Chemical Name: (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate
• CAS No.: 1585214-85-2
• Molecular Formula: C₁₈H₂₁NO₄S
• Molecular Weight: 347.435
• Mol file: 1585214-85-2.mol

Synonyms:(S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate

Chemical Property of (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate

There total 11 articles about (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

rac-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-69-2) → (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-85-2) + (R)-ethyl 3-hydroxy-3-(2-phenylthiazol-4-yl)propanoate (1585214-81-8)

Guidance literature:

With Candida antarctica lipase B; ethanol; In di-isopropyl ether; for 17h; Solvent; Reagent/catalyst; enantioselective reaction; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.tetasy.2014.01.013

Reference yield:

rac-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-69-2) → (R)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-73-8) + (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-85-2)

Guidance literature:

With Chiralpak IB column; In hexane; isopropyl alcohol; Resolution of racemate;

DOI:10.1016/j.tetasy.2014.01.013

Reference yield:

rac-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-69-2) → (R)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-73-8) + (S)-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate (1585214-85-2) + (R)-ethyl 3-hydroxy-3-(2-phenylthiazol-4-yl)propanoate (1585214-81-8)

Guidance literature:

With Candida antarctica lipase B; ethanol; In toluene; for 14h; Reagent/catalyst; Solvent; enantioselective reaction; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.tetasy.2014.01.013

upstream raw materials:

rac-2-(ethoxycarbonyl)-1-(2-phenylthiazol-4-yl)ethyl butanoate

2-phenyl-thiazole-4-carbaldehyde

rac-ethyl 3-hydroxy-3-(2-phenylthiazol-4-yl)propanoate