(3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

Base Information

Chemical Name:(3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one
CAS No.:193953-54-7
Molecular Formula:C₁₉H₁₇NO₃
Molecular Weight:307.349
Hs Code.:

Synonyms:(3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

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Chemical Property of (3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

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Technology Process of (3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

There total 4 articles about (3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 135969-64-1
(3aS,8aR)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

: 645-45-4
hydrocinnamic acid chloride

: 193953-54-7
(3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

Guidance literature:: (3aS,8aR)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

hydrocinnamic acid chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol2023328

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(1S,2R)-1-amino-2-indanol

: 193953-54-7
(3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 0 °C / Inert atmosphere

1.2: 2 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/ol2023328

Reference yield:

: 501-52-0
3-Phenylpropionic acid

: 193953-54-7
(3aS,8aR)-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 3 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; In tetrahydrofuran; hexane;
DOI:10.1002/adsc.201701474