ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

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Chemical Name:ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate
CAS No.:217977-54-3
Molecular Formula:C₂₇H₃₄N₂O₇
Molecular Weight:498.576
Hs Code.:

Synonyms:ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

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Chemical Property of ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

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Technology Process of ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

There total 1 articles about ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 41840-28-2
S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine

: (S)-2-[(S)-3-(4-Hydroxy-benzyl)-2-oxo-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propionic acid ethyl ester

: 217977-54-3
ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

Guidance literature:: In dichloromethane; for 48h; Ambient temperature;
DOI:10.1248/cpb.45.1940

Reference yield: 90.0%

: 217977-54-3
ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

: 201293-50-7
(S)-4-[(S)-1-Carboxy-2-(4-hydroxy-phenyl)-ethyl]-2-(4-hydroxy-benzyl)-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; In methanol; for 5h; Ambient temperature;
DOI:10.1248/cpb.45.1940

Reference yield:

: 217977-54-3
ethyl (2S)-3-(4-hydroxyphenyl)-2-<(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl>propionate

: 217977-63-4
(S)-2-(4-Benzyloxy-benzyl)-4-[(S)-2-(4-benzyloxy-phenyl)-1-carboxy-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran

2: LiOH, H₂O

3: 1.) BH₃, 2.) LiOH, H₂O / 1.) THF, r.t., 5 h, 2.) THF

With lithium hydroxide; borane; water; sodium hydride; In tetrahydrofuran;
DOI:10.1055/s-1998-2192