5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

Base Information

Chemical Name:5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate
CAS No.:1415929-00-8
Molecular Formula:C₁₃H₁₃F₄NO₃S
Molecular Weight:339.311
Hs Code.:

Synonyms:5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

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Chemical Property of 5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

There total 4 articles about 5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1415928-99-2
5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenol hydrochloride

: 1415929-00-8
5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 112204-58-7
5-Bromo-2-fluorophenol

: 1415929-00-8
5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogenchloride; methanol / 1,4-dioxane; tetrahydrofuran / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 - 20 °C

With hydrogenchloride; methanol; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1185836-54-7
4-bromo-1-fluoro-2-(methoxymethoxy)benzene

: 1415929-00-8
5-(7-azabicyclo[2.2.1]heptan-7-yl)-2-fluorophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride; methanol / 1,4-dioxane; tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 - 20 °C

With hydrogenchloride; methanol; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane;