Technology Process of (+/-)-1-(2-iodophenyl)-3-methylbut-3-en-2-ol
There total 5 articles about (+/-)-1-(2-iodophenyl)-3-methylbut-3-en-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C11H13IO;
With
aluminum isopropoxide;
In
toluene;
for 12h;
Inert atmosphere;
Reflux;
With
hydrogenchloride; water;
In
diethyl ether; toluene;
at 20 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2009.05.020
- Guidance literature:
-
With
sodium tetrahydroborate; cerium(III) chloride heptahydrate;
In
methanol;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1021/acs.orglett.6b02665
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium diacetate; [bis(acetoxy)iodo]benzene; iodine / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere
2: 1,1'-carbonyldiimidazole; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3: tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
4: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 0.17 h / 0 °C / Inert atmosphere
With
sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; cerium(III) chloride heptahydrate; iodine; palladium diacetate; triethylamine; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2: |Weinreb Ketone Synthesis / 4: |Luche Cerium Reduction;
DOI:10.1021/acs.orglett.6b02665
