Technology Process of 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)benzene-1,2-diamine
There total 4 articles about 4-(5-methoxy-4-morpholin-4-ylpyrimidin-2-yl)benzene-1,2-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on carbon;
In
methanol; ethyl acetate;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene / -10 - 20 °C
2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / Reflux
3: hydrogen / palladium on carbon / ethyl acetate; methanol / 20 °C
With
hydrogen; sodium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium on carbon;
In
1,4-dioxane; methanol; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trichlorophosphate; N,N-dimethyl-aniline / Cooling with ice; Reflux
2: toluene / -10 - 20 °C
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / Reflux
4: hydrogen / palladium on carbon / ethyl acetate; methanol / 20 °C
With
hydrogen; sodium carbonate; N,N-dimethyl-aniline; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); palladium on carbon;
In
1,4-dioxane; methanol; ethyl acetate; toluene;