(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

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Chemical Name:(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester
CAS No.:300831-65-6
Molecular Formula:C₄₂H₅₂N₄O₉
Molecular Weight:756.896
Hs Code.:

(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

Synonyms:(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

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Chemical Property of (1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

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Technology Process of (1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

There total 4 articles about (1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 300831-37-2
Boc-Thr(All)-OH

: (1R,2R)-2-But-3-enyl-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-cyclopropanecarboxylic acid methyl ester; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 300831-65-6
(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/j.jorganchem.2006.09.027

Reference yield:

: 300831-36-1
(2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyric acid methyl ester

: 300831-65-6
(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 200 mg / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 2 h / 20 °C

2: 32 percent / DIPEA; HATU / dimethylformamide / 20 h / 20 °C

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2006.09.027

Reference yield:

: 2592-18-9
Boc-Thr-OH

: 300831-65-6
(1R,2R)-1-{[(2S,4R)-1-((2S,3R)-3-Allyloxy-2-tert-butoxycarbonylamino-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-but-3-enyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 0.534 g / CH₂Cl₂; methanol

2: 99 mg / Ag₂O; 4A MS / diethyl ether / 36 h / Heating

3: 200 mg / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 2 h / 20 °C

4: 32 percent / DIPEA; HATU / dimethylformamide / 20 h / 20 °C

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; silver(l) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2006.09.027