(2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol

Base Information

Chemical Name:(2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol
CAS No.:1252686-71-7
Molecular Formula:C₁₈H₂₀N₄OS
Molecular Weight:340.449
Hs Code.:

Synonyms:(2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol

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Chemical Property of (2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol

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Technology Process of (2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol

There total 1 articles about (2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1252686-68-2
tert-butyl 4-[(1S)-1-benzyl-2-hydroxyethyl]amino-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylate

: 1252686-71-7
(2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol

Guidance literature:: tert-butyl 4-[(1S)-1-benzyl-2-hydroxyethyl]amino-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

With sodium hydrogencarbonate; In water; Inert atmosphere;
DOI:10.1021/jm100607r

Reference yield:

: 13991-36-1
4-bromocrotonic acid

: 1252686-71-7
(2S)-3-phenyl-2-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)propan-1-ol

: C₂₂H₂₃BrN₄O₂S

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm100607r