(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

Base Information

Chemical Name:(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate
CAS No.:674776-34-2
Molecular Formula:C₂₂H₂₂N₂O₃
Molecular Weight:362.428
Hs Code.:

Synonyms:(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

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Chemical Property of (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

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Technology Process of (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

There total 9 articles about (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 169221-13-0
(R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one

: 674776-31-9
3-cyano-2-phenyl-propionyl chloride

: 674776-34-2
(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

: (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2S)-3-cyano-2-phenylpropionate

Guidance literature:: With 3 A molecular sieve; triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.tetasy.2003.10.035

Reference yield:

: 442542-97-4
(+/-)-3-cyano-2-phenylpropionic acid

: 674776-34-2
(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₅ / CCl₄ / 0.5 h / 40 °C

2: 60 percent / Et₃N; 3 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 0 °C

With 3 A molecular sieve; phosphorus pentachloride; triethylamine; In tetrachloromethane; dichloromethane;
DOI:10.1016/j.tetasy.2003.10.035

Reference yield:

: 169221-12-9
(S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone

: 674776-34-2
(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Et₃N; 3 Angstroem molecular sieves / CH₂Cl₂ / 0 °C

2: 96 percent / LiOH*H₂O; H₂O₂ / tetrahydrofuran / 0 °C

3: 60 percent / Et₃N; 3 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 0 °C

With lithium hydroxide; 3 A molecular sieve; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2003.10.035