2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol

Base Information

• Chemical Name: 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol
• CAS No.: 133733-22-9
• Molecular Formula: C₂₀H₂₃ClN₂O₂
• Molecular Weight: 358.868
• Mol file: 133733-22-9.mol

Synonyms:2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol

Chemical Property of 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol

There total 7 articles about 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-chlorohexane-1,2-diamine dihydrochloride (133733-23-0) + salicylaldehyde (90-02-8) → 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol (133733-22-9)

Guidance literature:

With sodium acetate; In ethanol; water; at 60 ℃; for 0.25h;

DOI:10.1039/P19930003023

Reference yield:

5-Hexen-1-ol (821-41-0) → 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol (133733-22-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 90 percent / pyridinium toluene-p-sulfonate / CH₂Cl₂ / 20 h / Ambient temperature

2: 98 percent / ICl, NaN₃ / acetonitrile / 20 h / Ambient temperature

3: 44 percent / NaN₃, Bu₄NBr / benzene; dimethylformamide / 20 h / Heating

4: 99 percent / Dowex 50Wx₈ acidic carbon-exchange resin / methanol / 3 h / Ambient temperature

5: 85 percent / SOCl₂ / CHCl₃; dimethylformamide / 6 h / Ambient temperature

6: 75 percent / PPh₃, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

7: 83 percent / NaOAc*3H₂O / ethanol; H₂O / 0.25 h / 60 °C

With hydrogenchloride; thionyl chloride; sodium azide; Dowex 50Wx₈ acidic carbon-exchange resin; tetrabutylammomium bromide; sodium acetate; pyridinium p-toluenesulfonate; Iodine monochloride; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1039/P19930003023

Reference yield:

5,6-diazidohexan-1-ol (154372-50-6) → 2,2'-<<1-(4-chlorobutyl)ethane-1,2-diyl>bis(nitrilomethylidyne)>diphenol (133733-22-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / SOCl₂ / CHCl₃; dimethylformamide / 6 h / Ambient temperature

2: 75 percent / PPh₃, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

3: 83 percent / NaOAc*3H₂O / ethanol; H₂O / 0.25 h / 60 °C

With hydrogenchloride; thionyl chloride; sodium acetate; triphenylphosphine; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1039/P19930003023

upstream raw materials:

6-chlorohexane-1,2-diamine dihydrochloride

salicylaldehyde

5-Hexen-1-ol

6-(tetrahydropyran-2-yloxy)hex-1-ene