(S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate

Base Information

• Chemical Name: (S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate
• CAS No.: 1611479-68-5
• Molecular Formula: C₂HF₃O₂*C₃₄H₄₅NO₄Si
• Molecular Weight: 673.845
• Mol file: 1611479-68-5.mol

Synonyms:(S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate

Chemical Property of (S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate

There total 1 articles about (S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trifluoroacetic acid (76-05-1) + (S)-2-{(1R,2R)-2-[(S)-1-Benzyl-2-(tert-butyl-diphenyl-silanyloxy)-ethoxycarbonyl]-1-methoxy-propyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (173180-10-4) → (S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate (1611479-68-5)

Guidance literature:

In dichloromethane; at 0 ℃; for 1h;

DOI:10.3762/bjoc.10.29

Reference yield: 8.0%

diethyl cyanophosphonate (2942-58-7) + (2S,3S)-1-((S)-1-(((2R,3S)-1-carboxy-2-methoxy-4-methylpentan-3-yl)(methyl)amino)-3-methyl-1-oxobutan-2-ylamino)-N,N,3-trimethyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate (1611479-66-3) + (S)-2-((3R,4R,7S)-7-benzyl-4,11,11-trimethyl-5-oxo-10,10-diphenyl-2,6,9-trioxa-10-siladodecan-3-yl)pyrrolidinium 2,2,2-trifluoroacetate (1611479-68-5) → (2R,3R)-((S)-1-(tert-butyldiphenylsilyloxy)-3-phenylpropan-2-yl) 3-((S)-1-(diethoxyphosphoryl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoate (1611479-89-0) + (2R,3R)-((S)-1-(tert-butyldiphenylsilyloxy)-3-phenylpropan-2-yl) 3-((S)-1-((3R,4S)-4-((S)-2-((2S,3S)-2-(dimethylamino)-3-methylpentanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoate (1611479-69-6) + C56H86N4O8Si

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.3762/bjoc.10.29

upstream raw materials:

trifluoroacetic acid

(S)-2-{(1R,2R)-2-[(S)-1-Benzyl-2-(tert-butyl-diphenyl-silanyloxy)-ethoxycarbonyl]-1-methoxy-propyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(2R,3R)-((S)-1-(tert-butyldiphenylsilyloxy)-3-phenylpropan-2-yl) 3-((S)-1-(diethoxyphosphoryl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoate

(2R,3R)-((S)-1-(tert-butyldiphenylsilyloxy)-3-phenylpropan-2-yl) 3-((S)-1-((3R,4S)-4-((S)-2-((2S,3S)-2-(dimethylamino)-3-methylpentanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoate