3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

Base Information

Chemical Name:3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide
CAS No.:99082-55-0
Molecular Formula:C₂₁H₂₆N₂O₄S
Molecular Weight:402.514
Hs Code.:

Synonyms:3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

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Chemical Property of 3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

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Technology Process of 3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

There total 1 articles about 3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 98661-42-8
1--6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 103-72-0
phenyl isothiocyanate

: 99082-55-0
3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

Guidance literature:: In benzene; for 1h; Heating;

Reference yield: 83.0%

: 99082-55-0
3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

: 124482-22-0
{(4S,4aS)-6,7-Dimethoxy-1-[(Z)-phenylimino]-4,4a,9,10-tetrahydro-3H-2-thia-10a-aza-phenanthren-4-yl}-methanol

Guidance literature:: With hydrogenchloride; In ethanol; for 0.5h; Heating;

Reference yield:

: 99082-55-0
3,4-dihydro-1-[2-hydroxy-1-(hydroxymethyl)ethyl]-6,7-dimethoxy-N-phenyl-2(1H)-isoquinolinecarbothioamide

: 124482-09-3
Benzoic acid (4S,4aS)-6,7-dimethoxy-1-[(Z)-phenylimino]-4,4a,9,10-tetrahydro-3H-2-thia-10a-aza-phenanthren-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) methyl iodide, 2) KOH / 1) MeOH, room temp., 3 h, 2) MeOH, 3 h

2: 34 percent / P₂S₅ / 3 h / 170 °C

3: 69 percent / pyridine / 2 h / Heating

With pyridine; potassium hydroxide; tetraphosphorus decasulfide; methyl iodide;