(R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Base Information

Chemical Name:(R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
CAS No.:329926-41-2
Molecular Formula:C₁₄H₁₇ClF₃NO₄S₂
Molecular Weight:419.873
Hs Code.:

Synonyms:(R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Chemical Property of (R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Technology Process of (R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

There total 6 articles about (R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: sodium thiomethanolate

: (2R)-N-[2-Chloro-3-fluoro-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

: 329926-41-2
(R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 128 ℃; for 20h;

Reference yield:

: 329927-06-2
2-Chloro-3-fluoro-4-(isopropylsulphanyl)-nitrobenzene

: 329926-41-2
(R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: iron(III) chloride; zinc / DMF (N,N-dimethyl-formamide); water / 2 h / 100 °C

2: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.25 h / -78 - 20 °C

4: dihydrogen peroxide; acetic acid / water / 4.5 h / 100 °C

5: 1-methyl-pyrrolidin-2-one / 20 h / 128 °C

With iron(III) chloride; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; triethylamine; zinc; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; DMF (N,N-dimethyl-formamide); dichloromethane; water;

Reference yield:

: 2-chloro-3-fluoro-4-(isopropylsulphanyl)aniline

: 329926-41-2
(R)-N-[2-Chloro-3-methylsulphanyl-4-(isopropylsulphonyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.25 h / -78 - 20 °C

3: dihydrogen peroxide; acetic acid / water / 4.5 h / 100 °C

4: 1-methyl-pyrrolidin-2-one / 20 h / 128 °C

With tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;