(3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide

Base Information

• Chemical Name: (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide
• CAS No.: 875877-46-6
• Molecular Formula: C₃₁H₄₆N₄O₆
• Molecular Weight: 570.729

Synonyms:(3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide

Chemical Property of (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide

There total 12 articles about (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-amino-2-hydroxyhexanoic acid amide hydrochloride + (S,S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-diazatricyclo[11.5.3.016,20]henicosa-13(21),14,16(20)-triene-18-carboxylic acid (367259-39-0) → (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.016,20]henicosa-13(21),14,16(20)-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide (875877-46-6)

Guidance literature:

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dichloromethane; N,N-dimethyl-formamide; at -20 ℃;

DOI:10.1021/jm050520a

Reference yield:

2-hydroxy-3-nitrohexanoic acid (367258-42-2) → (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.016,20]henicosa-13(21),14,16(20)-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide (875877-46-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 66 percent / H₂; acetic acid / Pd/C / 20 h / 20 °C / 3051.17 Torr

2.1: aq. NaOH / dioxane / 0.17 h / 0 °C

2.2: 89 percent / dioxane; H₂O / 1 h / 0 - 20 °C

3.1: 31 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; ammonium chloride / 4-methylmorpholine / dimethylformamide / -20 °C

4.1: 100 percent / HCl / dioxane / 3 h / 20 °C

5.1: 92 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; ammonium chloride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; 4-methyl-morpholine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050520a

Reference yield:

3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid (166196-06-1) → (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.016,20]henicosa-13(21),14,16(20)-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide (875877-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 31 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; ammonium chloride / 4-methylmorpholine / dimethylformamide / -20 °C

2: 100 percent / HCl / dioxane / 3 h / 20 °C

3: 92 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

With 4-methyl-morpholine; hydrogenchloride; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; 4-methyl-morpholine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050520a

upstream raw materials:

(S,S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-diazatricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid

2-hydroxy-3-nitrohexanoic acid

3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid

[1-(carbamoyl-hydroxy-methyl)-butyl]-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 875877-46-6 (3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid [1-(carbamoyl-hydroxy-methyl)-butyl]-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send