3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

Base Information

Chemical Name:3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate
CAS No.:1345983-26-7
Molecular Formula:C₂HF₃O₂*C₃₀H₄₂N₂O₇S
Molecular Weight:688.763
Hs Code.:

Synonyms:3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

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Chemical Property of 3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

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Technology Process of 3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

There total 20 articles about 3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.6%

: 1345984-20-4
dimethyl 3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioate

: 76-05-1
trifluoroacetic acid

: 1345983-26-7
3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

Guidance literature:: dimethyl 3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioate; With water; lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 4h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 393855-85-1
2-amino-2-butylhexanyl hydrogen sulfate

: 1345983-26-7
3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

1.2: 15 h / 85 °C

2.1: citric acid / toluene / 50 h / 130 °C / Reflux

3.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

4.2: 0.5 h

5.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

6.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C

6.2: 1 h / pH 12 / Cooling with ice

7.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

8.1: acetic acid / 1,2-dichloro-ethane / 1 h / 25 °C

8.2: 19 h

9.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 25 °C

With lithium aluminium tetrahydride; borane-THF; 1,3-bis-(diphenylphosphino)propane; water; dihydrogen peroxide; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; citric acid; potassium hydroxide; lithium hydroxide; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;

Reference yield:

: 393855-78-2
2-amino-2-butyl-hexanoic acid ethyl ester

: 1345983-26-7
3-({[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 65 °C

1.2: 2 h / 0 °C

2.1: chlorosulfonic acid / ethyl acetate / 3 h / 25 - 40 °C

3.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

3.2: 15 h / 85 °C

4.1: citric acid / toluene / 50 h / 130 °C / Reflux

5.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

6.2: 0.5 h

7.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

8.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C

8.2: 1 h / pH 12 / Cooling with ice

9.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

10.1: acetic acid / 1,2-dichloro-ethane / 1 h / 25 °C

10.2: 19 h

11.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 25 °C

With chlorosulfonic acid; lithium aluminium tetrahydride; borane-THF; 1,3-bis-(diphenylphosphino)propane; water; dihydrogen peroxide; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; citric acid; potassium hydroxide; lithium hydroxide; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; toluene;