(Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

Base Information

Chemical Name:(Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid
CAS No.:129599-84-4
Molecular Formula:C₂₇H₂₄FNO₄
Molecular Weight:445.49
Hs Code.:

Synonyms:(Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

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Chemical Property of (Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

Chemical Property:

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Technology Process of (Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

There total 12 articles about (Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: C₂₇H₂₆NO₃F

: 129599-84-4
(Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

Guidance literature:: With jones reagent; In acetone; at 0 ℃; for 1h;
DOI:10.1002/anie.200604246

Reference yield:

: 132584-55-5
(Z)-2-Fluoro-4-phenyl-but-2-enal

: 129599-84-4
(Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: toluene / -70 °C

2: 78 percent / LAH / diethyl ether

3: 1.) NaH / 1.) hexane, THF, 2.) ether

4: xylene / 140 °C

5: 98 percent / H₂SO₄ / methanol

6: aq. NaOH / methanol

7: CH₂Cl₂

8: 76 percent / Jones oxidation

9: HCl / dioxane

10: NEt₃ / NEt₃

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; triethylamine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; toluene; xylene;
DOI:10.1016/S0040-4039(00)88549-4

Reference yield:

: 955038-33-2
(E)-Ethyl-2-fluoro-4-phenyl-2-butenoate

: 129599-84-4
(Z)-(S)-5-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-fluoro-6-phenyl-hex-3-enoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: DIBAH

2: toluene / -70 °C

3: 78 percent / LAH / diethyl ether

4: 1.) NaH / 1.) hexane, THF, 2.) ether

5: xylene / 140 °C

6: 98 percent / H₂SO₄ / methanol

7: aq. NaOH / methanol

8: CH₂Cl₂

9: 76 percent / Jones oxidation

10: HCl / dioxane

11: NEt₃ / NEt₃

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; diisobutylaluminium hydride; triethylamine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; toluene; xylene;
DOI:10.1016/S0040-4039(00)88549-4