2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

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Chemical Name:2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene
CAS No.:881812-36-8
Molecular Formula:C₇₁H₄₃F₁₂N
Molecular Weight:1138.11
Hs Code.:

2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3<i>H</i>-4-aza-cyclohepta[2,1-<i>a</i>;3,4-<i>a</i>']dinaphthalene

Synonyms:2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

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Chemical Property of 2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

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Technology Process of 2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

There total 12 articles about 2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2,6-dibromo-4-methyl-4,5-dihydro-3H-4-azacyclohepta[2,1-a;3,4a']dinaphthalene

: 881812-07-3
2,4-bis(4-trifluoromethylphenyl)-1-naphthylboronic acid

: 881812-36-8
2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

Guidance literature:: With palladium diacetate; triphenylphosphine; cesium fluoride; In N,N-dimethyl-formamide; at 90 ℃; for 24h;
DOI:10.1021/ja058066n

Reference yield:

: 881811-91-2
2,4-bis(4-trifluoromethylphenyl)-1-naphthylamine

: 881812-36-8
2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. H₂SO₄ / 8 h / 50 °C

1.2: aq. NaNO₂ / 0.5 h / 0 °C

1.3: aq. KI / 4 h / Heating

2.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: hexane; tetrahydrofuran / 20 °C

3.1: aq. HCl / hexane; tetrahydrofuran

4.1: Pd(OAc)2; PPh₃; CsF / dimethylformamide / 24 h / 90 °C

With hydrogenchloride; palladium diacetate; n-butyllithium; sulfuric acid; triphenylphosphine; cesium fluoride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 4.1: Suzuki-Miyaura coupling;
DOI:10.1021/ja058066n

Reference yield:

: 881811-99-0
1-iodo-2,4-bis(4-trifluoromethylphenyl)naphthalene

: 881812-36-8
2,6-bis-[2,4-bis-(4-trifluoromethyl-phenyl)-naphthalen-1-yl]-4-methyl-4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

1.2: hexane; tetrahydrofuran / 20 °C

2.1: aq. HCl / hexane; tetrahydrofuran

3.1: Pd(OAc)2; PPh₃; CsF / dimethylformamide / 24 h / 90 °C

With hydrogenchloride; palladium diacetate; n-butyllithium; triphenylphosphine; cesium fluoride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 3.1: Suzuki-Miyaura coupling;
DOI:10.1021/ja058066n