2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

Base Information

Chemical Name:2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine
CAS No.:82995-89-9
Molecular Formula:C₂₈H₄₅N₅O₃SSi₂
Molecular Weight:587.934
Hs Code.:

Synonyms:2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

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Chemical Property of 2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

There total 3 articles about 2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 82995-88-8
9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-amino>purine

: 82995-89-9
2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; for 6h; Ambient temperature;
DOI:10.1021/jo00144a014

Reference yield:

: 13464-19-2
phenyl chlorothioformate

: 82995-89-9
2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / 5 h / 0 - 20 °C

2: 85 percent / aq. NaOH / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With pyridine; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/jo00144a014

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 82995-89-9
2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / 5 h / 0 - 20 °C

2: 85 percent / aq. NaOH / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With pyridine; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/jo00144a014