C₂₆H₃₈O₃

Base Information

• Chemical Name: C₂₆H₃₈O₃
• CAS No.: 1612775-43-5
• Molecular Formula: C₂₆H₃₈O₃
• Molecular Weight: 398.586
• Mol file: 1612775-43-5.mol

Synonyms:C₂₆H₃₈O₃

Chemical Property of C₂₆H₃₈O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₈O₃

There total 7 articles about C₂₆H₃₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

C9H12O4 (1612775-42-4) + triphenyl(11-phenylundecyl)phosphonium bromide (116385-00-3) → C26H38O3 (1612775-43-5)

Guidance literature:

triphenyl(11-phenylundecyl)phosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

C₉H₁₂O₄; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol501446w

Reference yield:

C24H32O5Si → C26H38O3 (1612775-43-5)

Guidance literature:

Multi-step reaction with 11 steps

1.1: N-iodo-succinimide; tetra-(n-butyl)ammonium iodide / dichloromethane / 21 h / 20 °C / Inert atmosphere

2.1: dmap / acetonitrile / 0.67 h / 0 °C / Inert atmosphere

3.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 0.5 h / Inert atmosphere; Reflux

4.1: trimethylaluminum / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: 1.5 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

6.1: potassium tert-butylate / tetrahydrofuran / 1.25 h / 0 °C / Inert atmosphere

6.2: 2 h / 0 °C / Inert atmosphere

7.1: iodine / water; tetrahydrofuran / 11 h / 0 °C / Inert atmosphere

8.1: tri-n-butyl-tin hydride / toluene / 0.33 h / Inert atmosphere; Reflux

9.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 19 h / 0 °C / Inert atmosphere

10.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

10.2: 0.5 h / -78 - 20 °C / Inert atmosphere

11.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere

11.2: 3 h / -78 - 20 °C / Inert atmosphere

With dmap; N-iodo-succinimide; n-butyllithium; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tetrabutyl ammonium fluoride; iodine; trimethylaluminum; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile; 3.1: |Barton-McCombie Deoxygenation / 6.1: |Wittig Olefination / 6.2: |Wittig Olefination / 10.1: |Swern Oxidation / 10.2: |Swern Oxidation / 11.1: |Wittig Olefination / 11.2: |Wittig Olefination;

DOI:10.1021/ol501446w

Reference yield:

C25H31IO4Si (1612775-39-9) → C26H38O3 (1612775-43-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tri-n-butyl-tin hydride / toluene / 0.33 h / Inert atmosphere; Reflux

2.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 19 h / 0 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere

4.2: 3 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; hexane; dichloromethane; toluene; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation / 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;

DOI:10.1021/ol501446w

upstream raw materials:

C₂₅H₃₁IO₄Si

C₉H₁₂O₄

triphenyl(11-phenylundecyl)phosphonium bromide

C₃₁H₃₄O₆SSi

Downstream raw materials:

plakortone L