3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 220474-64-6
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 241.301

Synonyms:3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

α,α-dideutero-N-(2-iodobenzyl)-N-methylphenacylamine (220474-79-3) → 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (220474-64-6)

Guidance literature:

With n-butyllithium;

DOI:10.3987/COM-98-8329

Reference yield:

2-[(2-Iodo-benzyl)-methyl-amino]-1-phenyl-ethanone (113258-89-2) → 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (220474-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / Et₃N; D₂O / CH₃OD / 2 h / 50 °C

2: 56 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

With n-butyllithium; water-d2; triethylamine; In tetrahydrofuran; hexane; deuteromethanol; 1: deuteration / 2: Cyclization;

DOI:10.3987/COM-99-8786

Reference yield: 45.0%

3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (220474-64-6) → C16H12(2)HNO + C16H15(2)H2N

Guidance literature:

With boron tribromide; In dichloromethane; acetonitrile; for 17h; Heating;

DOI:10.3987/COM-99-8786

upstream raw materials:

α,α-dideutero-N-(2-iodobenzyl)-N-methylphenacylamine

2-[(2-Iodo-benzyl)-methyl-amino]-1-phenyl-ethanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 220474-64-6 3,3-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Send

Send

Metric Ton KG G Pound L ML

Send

Send