(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone

Base Information

• Chemical Name: (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone
• CAS No.: 1443777-93-2
• Molecular Formula: C₁₆H₁₈ClN₃O
• Molecular Weight: 303.791
• Mol file: 1443777-93-2.mol

Synonyms:(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone

Chemical Property of (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone

There total 6 articles about (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + C11H8Cl2N2O (1353725-69-5) → (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone (1443777-93-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 20 ℃;

DOI:10.1016/j.ejmech.2013.03.048

Reference yield:

para-chloroacetophenone (99-91-2) → (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone (1443777-93-2)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium methylate / methanol / 20 °C

2: acetic acid; hydrazine hydrate / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 50 °C

4: water; lithium hydroxide / tetrahydrofuran / 70 °C

5: N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere; Reflux

6: N-ethyl-N,N-diisopropylamine / 20 °C

With water; sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: |Claisen Condensation;

DOI:10.1016/j.ejmech.2013.03.048

Reference yield:

1-methyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid (1015868-48-0) → (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone (1443777-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / 20 °C

With N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.ejmech.2013.03.048

upstream raw materials:

1-methyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid

piperidine

C₁₁H₈Cl₂N₂O

para-chloroacetophenone