tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

Base Information

Chemical Name:tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate
CAS No.:1141475-76-4
Molecular Formula:C₂₉H₂₉FN₂O₅
Molecular Weight:504.558
Hs Code.:

Synonyms:tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

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Chemical Property of tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

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Technology Process of tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

There total 10 articles about tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1141475-76-4
tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 48 h / 70 °C / Inert atmosphere

2: 96 h / Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

4: sodium hydroxide / ethanol / 1 h / 60 °C

5: N-ethyl-N,N-diisopropylamine / 0 - 20 °C / Inert atmosphere

6: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: 142031-67-2
methyl 4-bromo-3-(bromomethyl)benzoate

: 1141475-76-4
tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 h / Reflux

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

3: sodium hydroxide / ethanol / 1 h / 60 °C

4: N-ethyl-N,N-diisopropylamine / 0 - 20 °C / Inert atmosphere

5: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; toluene; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: 1141473-84-8
methyl 4-bromo-3-(methoxymethyl)benzoate

: 1141475-76-4
tert-butyl (2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

2: sodium hydroxide / ethanol / 1 h / 60 °C

3: N-ethyl-N,N-diisopropylamine / 0 - 20 °C / Inert atmosphere

4: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; toluene; acetonitrile;
DOI:10.1002/cmdc.201402557