Technology Process of (2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-5-isopropyl-1-methylpyrrolidine
There total 11 articles about (2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-5-isopropyl-1-methylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: tetrahydrofuran / 12 h / -78 - 20 °C
2: hydrogenchloride / ethanol; 1,4-dioxane / 0.5 h / 0 °C
3: triethylamine / dichloromethane
4: sarett reagent / N,N-dimethyl-formamide / 24 h / 20 °C
5: diethyl ether / 3 h / -78 - 20 °C
6: trifluoroacetic acid / 1 h / 20 °C
7: sodium hydroxide / water / pH 10 - 12
8: palladium 10% on activated carbon; hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 8 h
9: methanol / 3 h
With
hydrogenchloride; sarett reagent; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.037
- Guidance literature:
-
Multi-step reaction with 10 steps
1: copper(II) sulfate; pyridinium p-toluenesulfonate / dichloromethane / 19 h
2: tetrahydrofuran / 12 h / -78 - 20 °C
3: hydrogenchloride / ethanol; 1,4-dioxane / 0.5 h / 0 °C
4: triethylamine / dichloromethane
5: sarett reagent / N,N-dimethyl-formamide / 24 h / 20 °C
6: diethyl ether / 3 h / -78 - 20 °C
7: trifluoroacetic acid / 1 h / 20 °C
8: sodium hydroxide / water / pH 10 - 12
9: palladium 10% on activated carbon; hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 8 h
10: methanol / 3 h
With
hydrogenchloride; sarett reagent; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; pyridinium p-toluenesulfonate; copper(II) sulfate; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.037
