(E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole

Base Information

• Chemical Name: (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole
• CAS No.: 1620206-54-3
• Molecular Formula: C₁₆H₁₈Cl₃NO
• Molecular Weight: 346.684
• Mol file: 1620206-54-3.mol

Synonyms:(E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole

Chemical Property of (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole

There total 3 articles about (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(E)-N-(1-bromo-4-(4-(tert-butyl)phenyl)but-3-en-2-yl)-2,2,2-trichloroacetamide (1620206-38-3) → (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole (1620206-54-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃;

DOI:10.1039/c4ob01126k

Reference yield:

1-(4-(tert-butyl)phenyl)but-3-en-1-ol (106027-36-5) → (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole (1620206-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

2: N-bromoacetamide / N,N-dimethyl-formamide / 6 h / 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 45 °C

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-bromoacetamide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4ob01126k

Reference yield:

C16H20Cl3NO (1620206-20-3) → (E)-4-(4-(tert-butyl)styryl)-2-(trichloromethyl)-4,5-dihydrooxazole (1620206-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromoacetamide / N,N-dimethyl-formamide / 6 h / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 45 °C

With potassium carbonate; N-bromoacetamide; In N,N-dimethyl-formamide;

DOI:10.1039/c4ob01126k

upstream raw materials:

(E)-N-(1-bromo-4-(4-(tert-butyl)phenyl)but-3-en-2-yl)-2,2,2-trichloroacetamide

C₁₆H₂₀Cl₃NO

1-(4-(tert-butyl)phenyl)but-3-en-1-ol