5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Base Information

Chemical Name:5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl
CAS No.:1093217-87-8
Molecular Formula:C₂₀H₂₅N₃O
Molecular Weight:323.438
Hs Code.:

Synonyms:5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Suppliers and Price of 5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

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Chemical Property of 5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Chemical Property:

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Technology Process of 5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

There total 6 articles about 5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622387-27-3
tert-butyl 4-(5-bromopyridin-2-yl)piperidine-1-carboxylate

: 186498-02-2
4-(4-morpholinyl)phenylboronic acid

: 1093217-87-8
5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Guidance literature:: tert-butyl 4-(5-bromopyridin-2-yl)piperidine-1-carboxylate; 4-(4-morpholinyl)phenylboronic acid; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 85 ℃; for 0.416667h; microwave;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane; water; pH=12;

Reference yield:

: 622387-27-3
tert-butyl 4-(5-bromopyridin-2-yl)piperidine-1-carboxylate

: 186498-02-2
4-(4-morpholinyl)phenylboronic acid

: 1093217-87-8
5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

: 1093217-86-7
5-(4-morpholin-4-ylphenyl)-3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 85 ℃; for 0.416667h; microwave;

Reference yield:

: 807618-13-9
(1-(tert-butoxycarbonyl)piperidine-4-yl)zinc(II) iodide

: 1093217-87-8
5-(4-morpholin-4-ylphenyl)-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.42 h / 85 °C / microwave

2.2: 1 h / 20 °C

2.3: pH 12

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,2-dimethoxyethane; water; acetonitrile;