(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

Base Information

Chemical Name:(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine
CAS No.:1407830-61-8
Molecular Formula:C₁₈H₁₆BrClN₄
Molecular Weight:403.709
Hs Code.:

Synonyms:(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

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Chemical Property of (R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

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Technology Process of (R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

There total 6 articles about (R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1407833-52-6
methyl 3-(2-amino-5-bromophenylamino)-2-methylpropanoate

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 1407830-58-3
(S)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / methanol / 0 - 20 °C

2: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

3: butan-1-ol / 12 h / 130 °C

4: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

5: Daicel AD-H / 38 °C / Resolution of racemate

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; sodium; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene; butan-1-ol;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 1407830-58-3
(S)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

6: Daicel AD-H / 38 °C / Resolution of racemate

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; sodium; iron; ammonium chloride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;

Reference yield:

: 1407833-56-0
7-bromo-3-methyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 1407830-58-3
(S)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

2: butan-1-ol / 12 h / 130 °C

3: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

4: Daicel AD-H / 38 °C / Resolution of racemate

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; toluene; butan-1-ol;