4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1204331-23-6
Molecular Formula:C₁₉H₂₄F₃NO₅
Molecular Weight:403.398
Hs Code.:

Synonyms:4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1204331-22-5
4-(4-carboxy-5-methoxy-2-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1204331-23-6
4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; acetic acid; platinum(IV) oxide; Inert atmosphere;

Reference yield:

: 1418273-57-0
C₂₀H₂₆F₃NO₅

: 1204331-23-6
4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: C₂₀H₂₆F₃NO₅; With lithium hydroxide monohydrate; In methanol; water; at 40 ℃;

With hydrogenchloride; In water; pH=5;
DOI:10.1021/jm300601d

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1204331-23-6
4-(4-carboxy-5-methoxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 °C

1.2: -75 - 0 °C

1.3: 0.17 h / Cooling

2.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 140 °C / Sealed tube

4.1: hydrogen; acetic acid / platinum(IV) oxide / Inert atmosphere

With hydrogen; potassium acetate; potassium carbonate; acetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; 3.1: Suzuki Coupling;