ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate

Base Information

• Chemical Name: ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate
• CAS No.: 104156-31-2
• Molecular Formula: C₂₀H₂₂O₅
• Molecular Weight: 342.392
• Mol file: 104156-31-2.mol

Synonyms:ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate

Chemical Property of ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate

There total 7 articles about ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-[(Z)-2-(2-Benzyloxy-3-ethoxycarbonylmethyl-phenyl)-vinyl]-benzoic acid methyl ester → ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate (104156-31-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 12h; under 3102.9 Torr;

DOI:10.1021/jm00161a033

Reference yield:

methyl 2-bromomethylbenzoate (2417-73-4) → ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate (104156-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / Heating

2: 1.) Na, EtOH / 1.) 3 min, 2.) EtOH, 45 min

3: 84 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 3102.9 Torr

With ethanol; hydrogen; sodium; palladium on activated charcoal; In ethanol; acetonitrile;

DOI:10.1021/jm00161a033

Reference yield:

2-Methyl-benzoic acid methyl ester (89-71-4) → ethyl 3-<2-(2-carbomethoxyphenyl)ethyl>-2-hydroxyphenylacetate (104156-31-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 1 h / Heating

2: acetonitrile / Heating

3: 1.) Na, EtOH / 1.) 3 min, 2.) EtOH, 45 min

4: 84 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 3102.9 Torr

With N-Bromosuccinimide; ethanol; hydrogen; sodium; dibenzoyl peroxide; palladium on activated charcoal; In tetrachloromethane; ethanol; acetonitrile;

DOI:10.1021/jm00161a033

upstream raw materials:

methyl 2-bromomethylbenzoate

2-Methyl-benzoic acid methyl ester

ethyl 2-(2-hydroxyphenyl)acetate

(2-methoxycarbonylbenzyl)triphenylphosphonium bromide

Downstream raw materials:

3-<2-(2-carboxyphenyl)ethyl>-2-hydroxyphenylacetic acid