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Thioctic acid

Base Information Edit
  • Chemical Name:Thioctic acid
  • CAS No.:1077-28-7
  • Deprecated CAS:62-46-4,27779-68-6,27779-68-6
  • Molecular Formula:C8H14O2S2
  • Molecular Weight:206.32
  • Hs Code.:29349990
  • European Community (EC) Number:214-071-2,200-534-6
  • NSC Number:758651,90788
  • UNII:73Y7P0K73Y
  • DSSTox Substance ID:DTXSID7025508
  • Nikkaji Number:J38.321J
  • Wikipedia:Lipoic_acid
  • Wikidata:Q312229
  • NCI Thesaurus Code:C61595
  • RXCUI:6417
  • ChEMBL ID:CHEMBL33864
  • Mol file:1077-28-7.mol
Thioctic acid

Synonyms:Acid, alpha-Lipoic;Alpha Lipogamma;alpha Lipoic Acid;Alpha Lipon Stada;alpha Liponaure Heumann;Alpha Liponsaure Sofotec;alpha Liponsaure von ct;Alpha Lippon AL;alpha Vibolex;Alpha-Lipogamma;alpha-Lipoic Acid;Alpha-Lipon Stada;alpha-Liponaure Heumann;Alpha-Liponsaure Sofotec;alpha-Liponsaure von ct;Alpha-Lippon AL;alpha-Vibolex;Alphaflam;AlphaLipogamma;AlphaLipon Stada;alphaLiponaure Heumann;AlphaLiponsaure Sofotec;alphaLiponsaure von ct;AlphaLippon AL;alphaVibolex;Azulipont;biomo lipon;biomo-lipon;biomolipon;duralipon;espa lipon;espa-lipon;espalipon;Fenint;Injekt, Thiogamma;Juthiac;Lipoic Acid;Liponsaure ratiopharm;Liponsaure-ratiopharm;Liponsaureratiopharm;MTW Alphaliponsaure;MTW-Alphaliponsaure;MTWAlphaliponsaure;Neurium;Pleomix Alpha;Pleomix Alpha N;Pleomix-Alpha;Pleomix-Alpha N;PleomixAlpha;PleomixAlpha N;Thioctacid;Thioctacide T;Thioctic Acid;Thiogamma Injekt;Thiogamma oral;Tromlipon;Verla Lipon;Verla-Lipon;VerlaLipon

Suppliers and Price of Thioctic acid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • racα-LipoicAcid
  • 10g
  • $ 75.00
  • TRC
  • racα-LipoicAcid
  • 5g
  • $ 70.00
  • TCI Chemical
  • DL-alpha-Lipoic Acid >99.0%(T)
  • 5g
  • $ 64.00
  • TCI Chemical
  • DL-alpha-Lipoic Acid >99.0%(T)
  • 25g
  • $ 196.00
  • Sigma-Aldrich
  • (±)-α-Lipoic acid synthetic, ≥99% (titration), powder
  • 50g
  • $ 503.00
  • Sigma-Aldrich
  • (±)-α-Lipoic acid ≥98.0%
  • 25 g
  • $ 288.00
  • Sigma-Aldrich
  • Thioctic acid European Pharmacopoeia (EP) Reference Standard
  • y0000546
  • $ 190.00
  • Sigma-Aldrich
  • Thioctic acid containing impurity B European Pharmacopoeia (EP) Reference Standard
  • y0000545
  • $ 190.00
  • Sigma-Aldrich
  • Thioctic acid for system suitability European Pharmacopoeia (EP) Reference Standard
  • y0000592
  • $ 190.00
  • Sigma-Aldrich
  • Alpha Lipoic Acid United States Pharmacopeia (USP) Reference Standard
  • 500mg
  • $ 325.00
Total 294 raw suppliers
Chemical Property of Thioctic acid Edit
Chemical Property:
  • Appearance/Colour:light yellow to yellow powder 
  • Melting Point:60-62 °C 
  • Refractive Index:1.5200 (estimate) 
  • Boiling Point:362.5 °C at 760 mmHg 
  • PKA:4.75±0.10(Predicted) 
  • Flash Point:173 °C 
  • PSA:87.90000 
  • Density:1.218 g/cm3 
  • LogP:2.78510 
  • Storage Temp.:2-8°C 
  • Solubility.:ethanol: 50 mg/mL 
  • Water Solubility.:0.9 g/L (20 ºC) 
  • XLogP3:1.7
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:5
  • Exact Mass:206.04352203
  • Heavy Atom Count:12
  • Complexity:150
Purity/Quality:

99%, *data from raw suppliers

racα-LipoicAcid *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn 
  • Hazard Codes:Xn 
  • Statements: 22-20/21/22 
  • Safety Statements: 37/39-26-24/25-36-36/37/39 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1CSSC1CCCCC(=O)O
  • Recent ClinicalTrials:Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
  • Recent EU Clinical Trials:Sensory Motor Neuropathies of the sciatic nerve: a comparative evaluation of dextrorotatory enantiomer of thioctic acid and acetyl-L-carnitine.
  • Description DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant. DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
  • Uses Lipoic acid [CAS: 1077-28-7] (6,8-dimercaptooctanoic acid), a lipophilic endogenous disulfide that can be reduced to the dithiol dihydrolipoic acid, protects against free-radical-mediated injury both in vivo and in vitro. thioctic acid is also known as alpha lipoic acid. It is an anti-oxidant. (±)-α-Lipoic acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay. It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period. A fat-metabolism stimulator
  • Therapeutic Function Growth factor, Lipotropic, Detoxicant
Technology Process of Thioctic acid

There total 105 articles about Thioctic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With potassium hydroxide; In methanol; at 20 ℃; for 24h;
DOI:10.1055/s-2005-861867
Guidance literature:
With hydrogenchloride; In benzene; at 50 ℃; for 7h;
DOI:10.1055/s-2005-865217
Guidance literature:
With piperidinium thiotungstate; In N,N-dimethyl-formamide; at 50 ℃; for 4h;
DOI:10.1021/jo00032a019
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