N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

Base Information

Chemical Name:N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide
CAS No.:871672-09-2
Molecular Formula:C₂₅H₂₇N₅O₅
Molecular Weight:477.52
Hs Code.:

<i>N</i>-cyclopropyl-<i>N</i>'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-<i>d</i>][1,3]dioxol-4-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl]-oxalamide

Synonyms:N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

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Chemical Property of N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

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Technology Process of N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

There total 3 articles about N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871672-08-1
N-cyclopropyloxalylamide monomethyl ester

: 871671-50-0
4-amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

: 871672-09-2
N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

Guidance literature:: 4-amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; With potassium tert-butylate; In tetrahydrofuran; at -10 ℃; for 0.25h;

N-cyclopropyloxalylamide monomethyl ester; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/jm050394a

Reference yield:

: 158112-53-9
(3aR,6R,6aR)-2,2,6-trimethyltetrahydro-2H-furo(3,4-d)(1,3)dioxol-4-ol

: 871672-09-2
N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride / dimethylformamide; acetonitrile

2.1: KOH; TDA-1 / acetonitrile / 2 h / 20 °C

2.2: 52 percent / toluene / 16 h / 20 °C

3.1: t-BuOK / tetrahydrofuran / 0.25 h / -10 °C

3.2: tetrahydrofuran / 18 h / 20 °C

With potassium hydroxide; oxalyl dichloride; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm050394a

Reference yield:

: 291535-34-7
5-deoxy-2,3-O-isopropylidene-α-D-ribofuranosyl chloride

: 871672-09-2
N-cyclopropyl-N'-[5-phenyl-7-(2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-oxalamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: KOH; TDA-1 / acetonitrile / 2 h / 20 °C

1.2: 52 percent / toluene / 16 h / 20 °C

2.1: t-BuOK / tetrahydrofuran / 0.25 h / -10 °C

2.2: tetrahydrofuran / 18 h / 20 °C

With potassium hydroxide; potassium tert-butylate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm050394a